The prompt of this post is in a research article I was reading:
Relationship between Plasma Levels of Lipopolysaccharides (LPS) and LPS-Binding Proteins in Patients with Severe Sepsis and Septic Shock; Steven M. Opal, Patrick J. Scannon, et al.; The Journal of Infectious Diseases; 1999; 180:1584-1589
"Administration of endotoxin to humans in minute quantities (2-4ng/kg) precipitates typical signs and symptoms of clinical sepsis, activates the complement and coagulation systems, and triggers release of the proinflammatory cytokines. Injection of larger doses of endotoxin (~1mg) into humans has been followed by severe hypotension and multiorgan dysfunction within 2 h of intravenous administration.
The part that caught my eye was "endotoxin into humans", and I couldn't help but wonder how the bloody hell they ever got that protocol approved, and how much did they have to pay the volunteers? So I flipped to the reference:
Brief Report: shock and multiple organ dysfunction after self administration of Salmonella endotoxin; daSilva AMT, Fromm RE, Chuidian FS; New England Journal of Medicine; 1993; 328:1457-60
The difference between a fool and a genius is slim indeed.