Toaster the Psychic Organ Builder

So the other day I was standing inside of a 4-story pneumatic pipe organ while it was being played thinking to myself: "Holy crap I'm inside of a 4-story pneumatic pipe organ while it is being played!" when it occurred to me that maybe I might actually know something. For a while I've been feeling like I have spent so much time and effort learning about molecular biology that I no longer know anything actually useful outside of the laboratory. This feeling was jade creeping into the awesomeness of science, and I found it best to promptly shake it off like a dog after a bath and go roll around on the floor joyously with all my legs in the air. I mean, sure this science sometimes appears to be nothing more than moving tiny amounts of expensive liquids around while muttering vague incantations about hypotheses and replicability. But what it is, what molecular biology fundamental is, is me dissecting LIFE ITSELF with my MIND!!! I could have all the fancy tools an R01 can buy at my disposal and a hammock above my bench, but those things wouldn't mean crap for meaningful, insightful science if I didn't start by designing an elegant, productive experiment. It's like I'm telekinetic at the molecular level, because I have to imagine the true nature of all these stochastically interacting proteins, genetic elements, or other molecules and their aggregate behavior clearly, I have to fix it in my mind and strip away the limitations of my vision to harness the quiet power of chemical reactions and hydrogen dipoles to prove the accuracy or folly of what I have captured with my mind.

Sure, this science doesn't have the immediate satisfaction of swinging a hammer and building a chair, the delay to sate the fundamental human need to create and explore burns on a longer fuse, but oh, when it connects it is all the more beautiful. I may not be building a pipe organ, but I am reverse-engineering something many more times intricate when I can't even see it with my naked eyes. That. Is. Awesome.

How to Explain the Senses?

Crowdsourcing: to open up the development process of any given project to the public in a meaningful way that allows the public to impact the course of that project's development.

Ann Arbor, Michigan is about to have a mini-Makers' Faire (as opposed to a Gigantic Makers' Faire). This entails a large gathering of creative people showing off the products of their creativity and ingenuity in a public forum. Typically there are demonstrations, learning, and sharing as most everything is open access. Basically, it is a gathering of nerds who like to make stuff teaching other nerds of similar aptitude, and the curious public, about the stuff they made. The purpose is to share, awe, inspire, educate, elucidate, demonstrate, and possibly also confuse.

I've gotten in on this, and a project is rapidly coalescing. In the Sensory Augmentation Devices booth, we're trying to demonstrate the electrical properties of nerves. However, to do this live and in real time, we must also tread carefully to avoid disgusting the public. Listed below are the ideas so far, and they are open to your comments and criticism.

1) Brain-ablated Xenopus (frog*) with thoracic cavity open connected to electrical leads at each limb in a physiological solution of potassium chloride. Each electrical lead will be run by a robotic sensor glove such that movement of the glove will induce neuromuscular contraction in the frog limbs. In effect, this is a frog puppet. We hope that the physiological potassion chloride solution will allow passive diffusion of ions back into nerve cells and allow for repeated contractions.

2) Similarly, brain-ablated Xenopus with thoracic cavity open and heart connected to an LED through a tranformer. The blinking LED will demonstrate to observers that the heart does indeed contract due to pulsed electrical impulses.

3) Petri dishes of rat or mouse neurons with silica implants connected to a computerized output to show random electrical activity of cultured neurons. We have a source of cultured neurons, but we still need a way to get a signal amplified out of them.

4) Brain model, either preserved real or plastic so that we can get the neuroscientists among us to explain the structural functionality of the brain and how it relates to neonatal development in humans, as well as anatomical siting of neural pathologies.

5) Setting up some of the basic sensory tricks, such as the Wet Illusion. In the Wet Illusion you place 2 cold metal bars against someone's bare skin with a warm bar sandwiched between them. Although all bars are quite dry, the brain registers the unusual temperature gradient as wetness. If you have other sensory tricks to use, let us know.

6) Electrode-based EEG interfaces hooked up to a sound synthesizer to allow the audience to "hear" the wearer's "thoughts". Getting the EEG output to interface with the sound synthesizer is the easy part, but getting a hold of the EEG/electrodes will be difficult.

7) 8-bit imager, where the audience may flip any of 64 switches to light up one of 64 LEDs in a board to explain how rhodopsin in the eye's cone cells converts light (the audience's hand) into an electical signal (the LED) by way of altering its molecular conformation (the state of the switch).



Any and all of this is completely open for your comment, criticism, and input. In fact, all 3 of those things are explicitly welcome! New demos may also be suggested, but the general theme of this is simply that we show how nerves and sense work.

*We figured that frogs are uncharismatic enough that no one, save the hard-core animal rights' activists, will have a major problem with using them for education purposes.

New Moral Compass

I think I have decided that this song is my new moral compass:


If ever I find myself questioning whether a given action is correct, moral, or ethical, I will play this song in the back of my head. It'll be like a Magic 8 Ball, not even I will know the mechanism of how exactly it works, but the answers it gives will just magically be correct.

This strikes me as a particularly good idea.

However, that could also be due to 3h of sleep from having to change a blown-out tire at 2am*, not arriving back at home until 4am, and trying to wash all of that down with vodka. I did, however, procure a large tube of industrial-strength epoxy and a ball of string last night, so that makes me happy. Dear readers, I am curious now what you think of me in the regard of: which do you think I will wind up getting into more trouble with? The epoxy or the string?

My new roommate also bought epoxy, although instead of string he opted for a lot of fake shrubbery. You can count on some guest blogging from him in the near future.

Roommate (left) and Toaster (right, wrapped in cape). Trust us, we know what we're doing: WE'RE SCIENTISTS!

*Yes, Roommate helped. Toaster tried to repay him with an apple fritter today, but he wasn't in his lab, so Sister Doom got it instead.